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The translational relevance of these observations to human subjects is unclear since, although men show an age-related decrease in serum ALLO, a similar age-dependent reduction in circulating levels of this neurosteroid is not seen in women (202)

The primary endpoint will be bodyweight change (week 80 and 104), change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in the OA subset, and change in Apnoea-Hypopnea Index (AHI) in the OSA subset

The role of BPC in the gastric juice is an important one

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